Open AccessEffect of KIF22 on promoting proliferation and migration of gastric cancer cells via MAPK-ERK pathways
Author(s) -
Zeyuan Yu,
Xiangyan Jiang,
Rongrong Zhao,
Junjie Qin,
Changjiang Luo,
Yanxian Ren,
Wen Xiu Ren,
Zhijian Ma,
Jiao Zhang
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000742
Subject(s) - mapk/erk pathway , cell cycle , cancer , cancer research , flow cytometry , cell growth , viability assay , biology , mek inhibitor , cancer cell , apoptosis , microbiology and biotechnology , kinase , chemistry , biochemistry , genetics
Gastric cancer (GC) is one of the most globally prevalent cancers in the world. The pathogenesis of GC has not been fully elucidated, and there still lacks effective targeted therapeutics. The influence of altered kinesin superfamily protein 22 (KIF22) expression in GC progression is still unclearly. The aim of this study was to investigate the KIF22 effects on GC and related mechanisms.