Open AccessEndoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes
Author(s) -
Zhijian Cao,
Zhuan Wu,
Cong Hu,
Min Zhang,
Wu-Zhou Wang,
Xiaobo Hu
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000583
Subject(s) - endoplasmic reticulum , unfolded protein response , pancreatic islets , pathogenesis , microbiology and biotechnology , type 1 diabetes , medicine , diabetes mellitus , endocrinology , chemistry , biology , islet
Type 1 diabetes (T1D) results from dysfunction of pancreatic islets β cells. Recent studies supported that endoplasmic reticulum (ER) stress takes an important role in pancreatic β cell excessive loss, resulting in T1D. Here, we aimed to review the relationship between ER stress and T1D. Additionally, we also reviewed the potential mechanisms underlying ER stress mediated T1D. Studies have shown that severe ER stress is directly involved in the pancreatic β cells destruction and pathogenesis of T1D. ER stress plays a key part in pancreatic β cells and T1D, which will help in developing new effective therapeutics for T1D.