Open AccessDownregulation of miR-4772-3p promotes enhanced regulatory T cell capacity in malignant pleural effusion by elevating Helios levels
Author(s) -
Wenqing Yu,
Ningfei Ji,
Changjiang Gu,
Zhixiao Sun,
Zhengxia Wang,
Zhongqi Chen,
Yuan Ma,
Zhenzhen Wu,
Yanli Wang,
Chaojie Wu,
Mingdong Ding,
Guihong Dai,
Juan Yao,
Renshun Jin,
Mao Huang,
Mingshun Zhang
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000517
Subject(s) - downregulation and upregulation , microrna , flow cytometry , cancer research , immune system , malignant pleural effusion , peripheral blood mononuclear cell , medicine , in vitro , immunology , biology , pleural effusion , gene , biochemistry
Malignant pleural effusion (MPE) is a complicated condition of patients with advanced tumors. Further dissecting the microenvironment of infiltrated immune cells and malignant cells are warranted to understand the immune-evasion mechanisms of tumor development and progression.