Open AccessEffect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy
Author(s) -
Zhisheng Wu,
Wenli Huang,
Shu-Jie Gong
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000496
Subject(s) - neuroinflammation , pten , oxidative stress , tensin , malondialdehyde , status epilepticus , superoxide dismutase , endocrinology , nissl body , medicine , chemistry , epilepsy , biology , pathology , pi3k/akt/mtor pathway , apoptosis , neuroscience , biochemistry , staining , inflammation
Epilepsy is a chronic and severe neurological disorder. Phosphatase and tensin homolog deleted on chromosome ten (PTEN)-deficient mice exhibit learning and memory deficits and spontaneous epilepsy. The aim of this study was to investigate the role of PTEN in brain oxidative damage and neuroinflammation in a rat model of epilepsy.