Open AccessTumor-suppressor microRNA-139-5p restrains bladder cancer cell line ECV-304 properties via targeting Connexin 43
Author(s) -
Qiang Chi,
Zhiyong Wang,
Hongyang Li,
Dianbin Song,
Hui Xu,
Guoying Ma,
Zemin Wang,
Xiu-Ming Li
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000455
Subject(s) - microrna , carcinogenesis , connexin , bladder cancer , cell culture , cancer research , cell growth , suppressor , blot , biology , transfection , microbiology and biotechnology , cancer , gap junction , gene , genetics , intracellular
In our previous paper, we demonstrated that Connexin 43 (CX43) was highly expressed in bladder cancer (BC) tissues. But the molecular mechanism about microRNAs (miRNAs) regulation upstream of CX43 in BC has not been well elucidated and remains to be further studied. MicroRNA-139-5p (miR-139-5p) is a tumor suppressor in progression of multifarious cancers including BC. Nevertheless, the underlying mechanisms of CX43/miR-139-5p in tumorigenesis of BC are still not well illustrated. The specific objective of our study was to inquiry the effect of CX43/miR-139-5p on BC progression and its underlying mechanism.