Open AccessInvolvement of phosphatase and tensin homolog-induced putative kinase 1–Parkin-mediated mitophagy in septic acute kidney injury
Author(s) -
Xingui Dai,
Wei Xu,
Tao Li,
Jiaying Lu,
Yang Yang,
Qiong Li,
Zhenhua Zeng,
Yuhang Ai
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000448
Subject(s) - mitophagy , parkin , tensin , pink1 , autophagy , microbiology and biotechnology , apoptosis , biology , chemistry , cancer research , signal transduction , pi3k/akt/mtor pathway , medicine , pten , biochemistry , disease , parkinson's disease
Studies have reported mitophagy activation in renal tubular epithelial cells (RTECs) in acute kidney injury (AKI). Phosphatase and tensin homolog-induced putative kinase 1 (PINK1) and E3 ubiquitin-protein ligase Parkin are involved in mitophagy regulation; however, little is known about the role of PINK1-Parkin mitophagy in septic AKI. Here we investigated whether the PINK1-Parkin mitophagy pathway is involved in septic AKI and its effects on cell apoptosis in vitro and on renal functions in vivo.