Open AccessEarly-life stress alters sleep structure and the excitatory-inhibitory balance in the nucleus accumbens in aged mice
Author(s) -
Ting Wang,
Hongli Wang,
Rui Li,
Han Wang,
Yue Zhang,
Yan Sun,
YunAi Su,
Tianmei Si,
Jitao Li
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000279
Subject(s) - nucleus accumbens , sleep (system call) , inhibitory postsynaptic potential , physiology , medicine , endocrinology , neuroscience , psychology , central nervous system , computer science , operating system
Exposure to adverse experiences in early life may profoundly reshape the neurodevelopmental trajectories of the brain and lead to long-lasting behavioral and neural alterations. One deleterious effect of early-life stress that manifests in later life is sleep disturbance, but this has not been examined in aged mice and the underlying neural mechanisms remain unknown. Considering the important role of the nucleus accumbens (NAc) in the sleep-wake regulation, this study aimed to assess the effects of early-life stress on the sleep behaviors in aged mice and the potential involvement of the NAc in stress-induced sleep abnormalities.