Open AccessDL-3-n-butylphthalide protects the blood-brain barrier against ischemia/hypoxia injury via upregulation of tight junction proteins
Author(s) -
Zhan-Ying Ye,
Hanying Xing,
Bei Wang,
Min Liu,
Peiyuan Lv
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000232
Subject(s) - downregulation and upregulation , hypoxia (environmental) , tight junction , ischemia , blood–brain barrier , medicine , chemistry , pharmacology , biochemistry , oxygen , central nervous system , gene , organic chemistry
The increased permeability of the blood-brain barrier (BBB) induced by ischemia/hypoxia is generally correlated with alteration of tight junctions (TJs). DL-3-n-butylphthalide (NBP) has been shown to exert neuroprotective effects after ischemic injury. However, few studies have assessed the correlation between NBP and TJs. This study aimed to investigate the potential effect of NBP on the TJ proteins claudin-5, zonula occludens-1 (ZO-1), and occludin during brain ischemia.