Open AccessVimentin modulates apoptosis and inflammatory cytokine release by a human monocytic cell line (THP-1) in response to lipopolysaccharides in vitro
Author(s) -
Longxiang Su,
Pan Pan,
Xiaoting Wang,
Yu Liang,
Dawei Liu,
Xiang Zhou
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000187
Subject(s) - vimentin , apoptosis , tumor necrosis factor alpha , thp1 cell line , cytokine , microbiology and biotechnology , monocyte , cell culture , biology , tunel assay , monocytic leukemia , immunology , cancer research , biochemistry , immunohistochemistry , genetics
It has recently been recognized that serum vimentin is elevated in infectious diseases, and that vimentin plays a role in regulating neutrophils and macrophages associated inflammation. However, the mechanisms are unclear. This study was designed to explore the role of vimentin in regulating monocyte survival or apoptosis as well as inflammatory cytokine secretion in response to lipopolysaccharides (LPSs).