Open AccessEndothelial glycocalyx as a potential theriapeutic target in organ injuries
Author(s) -
Rui-Na Cao,
Li Tang,
Zhongyuan Xia,
Rui Xia
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000177
Subject(s) - glycocalyx , medicine , inflammation , endothelium , vascular permeability , endothelial dysfunction , klf2 , pathology , immunology , biology , biochemistry , transcription factor , gene
The endothelial glycocalyx (eGC) is a dynamic and multicomponent layer of macromolecules found at the surface of vascular endothelium, which is largely underappreciated. It has recently been recognized that eGC is a major regulator of endothelial function and may have therapeutic value in organ injuries. This study aimed to explore the role of the eGC in various pathologic and physiologic conditions, by reviewing the basic research findings pertaining to the detection of the eGC and its clinical significance. We also explored different pharmacologic agents used to protect and rebuild the eGC.