Open AccessActivated mTOR signaling pathway in myofibers with inherited metabolic defect might be an evidence for mTOR inhibition therapies
Author(s) -
Jing-Wei Lyu,
Xuebi Xu,
Kunqian Ji,
Na Zhang,
Yuan Sun,
Dandan Zhao,
Yuying Zhao,
Chuanzhu Yan
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000144
Subject(s) - ribosomal protein s6 , pi3k/akt/mtor pathway , immunohistochemistry , phosphorylation , blot , cytochrome c oxidase , skeletal muscle , medicine , chemistry , endocrinology , myopathy , enzyme , signal transduction , p70 s6 kinase 1 , biochemistry , gene
Abnormally activated mechanistic target of rapamycin (mTOR) pathway has been reported in several model animals with inherited metabolic myopathies (IMMs). However, the profiles of mTOR pathway in skeletal muscles from patients are still unknown. This study aimed to analyze the activity of mTOR pathway in IMMs muscles.