Open AccessPharmacokinetic-pharmacodynamic analysis of ciprofloxacin in elderly Chinese patients with lower respiratory tract infections caused by Gram-negative bacteria
Author(s) -
Xiaoyan Gai,
Shining Bo,
Ning Shen,
Qingtao Zhou,
Anyue Yin,
Wei Lu
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000136
Subject(s) - ciprofloxacin , medicine , respiratory tract infections , pharmacokinetics , sputum , lower respiratory tract infection , pharmacodynamics , acinetobacter , acinetobacter baumannii , minimum inhibitory concentration , area under the curve , cmax , gastroenterology , pseudomonas aeruginosa , antibiotics , microbiology and biotechnology , respiratory system , biology , bacteria , tuberculosis , genetics , pathology
Ciprofloxacin is usually used in the treatment of lower respiratory tract infections (LRTIs). Recent studies abroad have shown ciprofloxacin is inadequately dosed and might lead to worse outcomes. The aim of this study was to perform pharmacokinetic and pharmacodynamic analyses of ciprofloxacin in elderly Chinese patients with severe LRTIs caused by Gram-negative bacteria.