Open AccessRole of mammalian target of rapamycin signaling pathway in regulation of fatty acid oxidation in a preeclampsia-like mouse model treated with pravastatin
Author(s) -
Jing Huai,
Zi Yang,
Yanhong Yi,
Guang-Jiao Wang
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000129
Subject(s) - pi3k/akt/mtor pathway , endocrinology , preeclampsia , medicine , chemistry , pravastatin , placenta , saline , beta oxidation , signal transduction , fatty acid , biochemistry , biology , fetus , pregnancy , cholesterol , genetics
Fatty acid oxidation (FAO) disorder is involved in the pathogenesis of some cases of preeclampsia (PE). Several studies show that mammalian target of rapamycin (mTOR) signaling pathway is related to FAO. Pravastatin (Pra) can promote FAO in Nω-nitro-L-arginine methyl ester (L-NAME) PE-like mouse model in our previous study. This study aimed to investigate the effect of mTOR signaling pathway in PE-like model treated with Pra.