Open AccessStudy on variation trend of repetitive nerve stimulation waveform in amyotrophic lateral sclerosis
Author(s) -
Lilan Fu,
Hexiang Yin,
Mingsheng Liu,
Liying Cui
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000117
Subject(s) - amyotrophic lateral sclerosis , stimulation , physical medicine and rehabilitation , nerve stimulation , medicine , neuroscience , variation (astronomy) , biology , physics , disease , astrophysics
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower motor neurons with no effective cure. Electrophysiological studies have found decremental responses during low-frequency repetitive nerve stimulation (RNS) except for diffused neurogenic activities. However, the difference between ALS and generalized myasthenia gravis (GMG) in terms of waveform features is unclear. In the current study, we explored the variation trend of the amplitudes curve between ALS and GMG with low-frequency, positive RNS, and the possible mechanism is discussed preliminarily.