Open AccessCathelicidin LL-37 restoring glucocorticoid function in smoking and lipopolysaccharide-induced airway inflammation in rats
Author(s) -
Jianzhen Weng,
Yan Wang,
Tieying Sun
Publication year - 2019
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000107
Subject(s) - medicine , budesonide , copd , tumor necrosis factor alpha , inflammation , lung , lipopolysaccharide , protein kinase b , glucocorticoid , pi3k/akt/mtor pathway , endocrinology , proinflammatory cytokine , dexamethasone , immunology , corticosteroid , phosphorylation , chemistry , signal transduction , biochemistry
Glucocorticoids have been widely used to treat patients with chronic obstructive pulmonary disease (COPD). Nevertheless, corticosteroid insensitivity is a major barrier to the effective treatment of COPD and its mechanism remains unclear. This study aimed to evaluate the effect of cathelicidin LL-37 on corticosteroid insensitivity in COPD rat model, and to explore the involved mechanisms.