Open AccessNovel DNA-based T-Cell Activator Promotes Rapid T-Cell Activation and Expansion
Author(s) -
Vandana Keskar,
Anup Sood,
Evelina Loghin,
Ernest Kovacs,
Ruth Duthie,
Shutong Liu,
Jee Hyun Park,
Chrystal Chadwick,
Richard Smith,
Martin J. Brown,
David F. Stroncek,
Steven L. Highfill
Publication year - 2020
Publication title -
journal of immunotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.805
H-Index - 92
eISSN - 1537-4513
pISSN - 1524-9557
DOI - 10.1097/cji.0000000000000329
Subject(s) - chimeric antigen receptor , cell , microbiology and biotechnology , cell growth , t cell , receptor , cancer research , chemistry , computational biology , immunology , biology , immune system , biochemistry
Autologous chimeric antigen receptor engineered T-cell therapies are beginning to dramatically change the outlook for patients with several hematological malignancies. Yet methods to activate and expand these cells are limited, often pose challenges to automation, and have biological limitations impacting the output of the injectable dose. This study describes the development of a novel, highly flexible, soluble DNA-based T-cell activation and expansion platform which alleviates the limitations of current technologies and provides rapid T-cell activation and expansion.