Open AccessAntiangiogenic approaches for the treatment of advanced synovial sarcomas
Author(s) -
Khanh Do,
James H. Doroshow,
Shivaani Kummar
Publication year - 2012
Publication title -
current opinion in oncology/current opinion in oncology, with cancerlit
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 95
eISSN - 1080-8140
pISSN - 1040-8746
DOI - 10.1097/cco.0b013e328354c141
Subject(s) - pazopanib , medicine , synovial sarcoma , sunitinib , sarcoma , sorafenib , oncology , vascular endothelial growth factor , soft tissue sarcoma , disease , vegf receptors , pathology , cancer , hepatocellular carcinoma
Synovial sarcomas are regarded as chemosensitive tumors compared to other types of soft tissue sarcomas, however, prognosis for advanced refractory disease remains poor. In light of the vascular nature of sarcomas, current molecularly targeted therapies aim at an antiangiogenic approach to management of this disease.