Open AccessTherapeutic targeting of the DNA damage response in prostate cancer
Author(s) -
Catherine Handy Marshall,
Emmanuel S. Antonarakis
Publication year - 2020
Publication title -
current opinion in oncology/current opinion in oncology, with cancerlit
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 95
eISSN - 1080-8140
pISSN - 1040-8746
DOI - 10.1097/cco.0000000000000617
Subject(s) - medicine , prostate cancer , dna repair , disease , germline , parp inhibitor , genetic testing , cancer , germline mutation , gene , somatic cell , oncology , bioinformatics , poly adp ribose polymerase , cancer research , mutation , genetics , polymerase , biology
The present article highlights the most common DNA repair gene mutations, using specific examples of individual genes or gene classes, and reviews the epidemiology and treatment implications for each one [with particular emphasis on poly-ADP-ribose polymerase (PARP) inhibition and PD-1 blockade].