Open AccessEmerging mechanistic underpinnings and therapeutic targets for chemotherapy-related cognitive impairment
Author(s) -
Elaine Gibson,
Michelle Monje
Publication year - 2019
Publication title -
current opinion in oncology/current opinion in oncology, with cancerlit
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 95
eISSN - 1080-8140
pISSN - 1040-8746
DOI - 10.1097/cco.0000000000000578
Subject(s) - neuroscience , medicine , microglia , synaptic plasticity , neuroplasticity , cognitive decline , neurotrophic factors , cancer , dementia , psychology , immunology , inflammation , disease , receptor
Modern innovations in cancer therapy have dramatically increased the number of cancer survivors. An unfortunately frequent side-effect of cancer treatment is enduring neurological impairment. Persistent deficits in attention, concentration, memory, and speed of information processing afflict a substantial fraction of cancer survivors following completion of these life-saving therapies. Here, we highlight chemotherapy-related cognitive impairment (CRCI) and discuss the current understanding of mechanisms underlying CRCI.