Open AccessDiffuse intrinsic pontine glioma: molecular landscape and emerging therapeutic targets
Author(s) -
Razina Aziz-Bose,
Michelle Monje
Publication year - 2019
Publication title -
current opinion in oncology/current opinion in oncology, with cancerlit
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 95
eISSN - 1080-8140
pISSN - 1040-8746
DOI - 10.1097/cco.0000000000000577
Subject(s) - medicine , glioma , immunotherapy , epigenetics , malignancy , neuroscience , bromodomain , cancer research , histone deacetylase , bioinformatics , histone , pathology , immunology , immune system , biology , biochemistry , gene
Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood brainstem malignancy. Despite advances in understanding of the molecular underpinnings of the tumor in the past decade, the dismal prognosis of DIPG has thus far remained unchanged. This review seeks to highlight promising therapeutic targets within three arenas: DIPG cell-intrinsic vulnerabilities, immunotherapeutic approaches to tumor clearance, and microenvironmental dependencies that promote tumor growth.