Open AccessFeasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: The MIND randomized, placebo-controlled trial*
Author(s) -
Timothy D. Girard,
Pratik P. Pandharipande,
Shan S. Carson,
Gregory A. Schmidt,
Patrick E. Wright,
Angelo E. Caico,
Brenda T. Pun,
Jennifer L. Thompson,
Ayumi Shintani,
Herbert Y. Meltzer,
Gordon R. Bernard,
Robert S. Dittus,
E. Wesley Ely
Publication year - 2010
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0b013e3181c58715
Subject(s) - medicine , delirium , placebo , haloperidol , ziprasidone , anesthesia , randomized controlled trial , intensive care unit , sedation , antipsychotic , psychomotor agitation , intensive care , coma (optics) , akathisia , surgery , psychiatry , intensive care medicine , schizophrenia (object oriented programming) , alternative medicine , pathology , dopamine , optics , physics
To demonstrate the feasibility of a placebo-controlled trial of antipsychotics for delirium in the intensive care unit and to test the hypothesis that antipsychotics would improve days alive without delirium or coma.