Open AccessAberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Author(s) -
Lisa Brubaker,
Arun Saini,
Trung C. Nguyen,
Marina Martínez-Vargas,
Fong Lam,
Qizhi Yao,
Michele M. Loor,
Todd K. Rosengart,
Miguel A. Crúz
Publication year - 2022
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000005465
Subject(s) - medicine , interquartile range , fibrin , sepsis , sofa score , disseminated intravascular coagulation , gastroenterology , immunology
Disseminated fibrin-rich microthrombi have been reported in patients who died from COVID-19. Our objective is to determine whether the fibrin clot structure and function differ between critically ill patients with or without COVID-19 and to correlate the structure with clinical coagulation biomarkers.