Open AccessIdentifying Prokineticin2 as a Novel Immunomodulatory Factor in Diagnosis and Treatment of Sepsis*
Author(s) -
Xiaoling Yu,
Jingyi Chen,
Hong Tang,
Qianqian Tu,
Yue Li,
Xi Yuan,
Xuemei Zhang,
Ju Cao,
David P. Molloy,
Yibing Yin,
Dapeng Chen,
Zigen Song,
Pingyong Xu
Publication year - 2021
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000005335
Subject(s) - sepsis , medicine , septic shock , shock (circulatory) , immunology , animal studies , inflammation , organ dysfunction , systemic inflammatory response syndrome
Sepsis remains a highly lethal disease, whereas the precise reasons for death remain poorly understood. Prokineticin2 is a secreted protein that regulates diverse biological processes. Whether prokineticin2 is beneficial or deleterious to sepsis and the underlying mechanisms remain unknown.