Open AccessIncreased Glucocorticoid Receptor Alpha Expression and Signaling in Critically Ill Coronavirus Disease 2019 Patients*
Author(s) -
Alice G. Vassiliou,
Nikolaos Athanasiou,
Chrysi Keskinidou,
Edison Jahaj,
Stamatios Tsipilis,
Alexandros Zacharis,
Efthimia Botoula,
Aristidis Diamantopoulos,
Ιoannis Ilias,
Dimitra Argyro Vassiliadi,
Stylianos Tsagarakis,
Αναστασία Κοτανίδου,
Ioanna Dimopoulou
Publication year - 2021
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000005097
Subject(s) - glucocorticoid receptor , glucocorticoid , medicine , endocrinology , receptor , hypercortisolemia , immunology , hydrocortisone
Critical illness is characterized by increased serum cortisol concentrations and bioavailability resulting from the activation of the hypothalamic-pituitary-adrenal axis, which constitutes an essential part of the stress response. The actions of glucocorticoids are mediated by a ubiquitous intracellular receptor protein, the glucocorticoid receptor. So far, data on coronavirus disease 2019 and glucocorticoid receptor alpha expression are lacking.