Open AccessIdentifying High-Risk Subphenotypes and Associated Harms From Delayed Antibiotic Orders and Delivery*
Author(s) -
Xuan Han,
A. Spicer,
Kyle Carey,
Emily Gilbert,
Neda Laiteerapong,
Nirav Shah,
Christopher Winslow,
Majid Afshar,
Markos Kashiouris,
Matthew M Churpek
Publication year - 2021
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000005054
Subject(s) - medicine , odds ratio , logistic regression , emergency medicine , sepsis , retrospective cohort study , medical record , subgroup analysis , comorbidity , pediatrics , intensive care medicine , confidence interval
Early antibiotic administration is a central component of sepsis guidelines, and delays may increase mortality. However, prior studies have examined the delay to first antibiotic administration as a single time period even though it contains two distinct processes: antibiotic ordering and antibiotic delivery, which can each be targeted for improvement through different interventions. The objective of this study was to characterize and compare patients who experienced order or delivery delays, investigate the association of each delay type with mortality, and identify novel patient subphenotypes with elevated risk of harm from delays.