Open AccessDesign of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III
Author(s) -
Denham S. Ward,
Anthony Absalom,
Leanne M. Aitken,
Michele C. Balas,
David Brown,
Lisa Burry,
Elizabeth Colantuoni,
Douglas B. Coursin,
John W. Devlin,
Franklin Dexter,
Robert H. Dworkin,
Talmage D. Egan,
Doug Elliott,
Ingrid Egerod,
Pamela Flood,
Gilles L. Fraser,
Timothy D. Girard,
David Gozal,
Ramona O. Hopkins,
John P. Kress,
Mervyn Maze,
Dale M. Needham,
Pratik P. Pandharipande,
Richard R. Riker,
Daniel I. Sessler,
Steven L. Shafer,
Yahya Shehabi,
Claudia Spies,
Lena S. Sun,
Avery Tung,
Richard D. Urman
Publication year - 2021
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000005049
Subject(s) - medicine , sedation , delirium , clinical trial , delphi method , multidisciplinary approach , mechanical ventilation , medline , standardization , intensive care medicine , psychiatry , surgery , social science , statistics , mathematics , pathology , sociology , political science , law
Clinical trials evaluating the safety and effectiveness of sedative medication use in critically ill adults undergoing mechanical ventilation differ considerably in their methodological approach. This heterogeneity impedes the ability to compare results across studies. The Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research Recommendations convened a meeting of multidisciplinary experts to develop recommendations for key methodologic elements of sedation trials in the ICU to help guide academic and industry clinical investigators.