Open AccessSafety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study
Author(s) -
Roger van Groenendael,
Remi Beunders,
Pleun Hemelaar,
Jan Hofland,
Wim J. Morshuis,
Johannes G. van der Hoeven,
Jelle Gerretsen,
Gert Wensvoort,
Emma J. Kooistra,
Wout J. Claassen,
Denise Waanders,
Maud G. A. Lamberts,
Leonie S. E. Buijsse,
Matthijs Kox,
Lucas T. van Eijk,
Peter Pickkers
Publication year - 2021
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000004847
Subject(s) - medicine , renal function , placebo , acute kidney injury , kidney disease , creatinine , urology , surgery , anesthesia , pathology , alternative medicine
To determine the safety and efficacy of human chorionic gonadotropin hormone-derivative EA-230 in cardiac surgery patients. Cardiac surgery induces systemic inflammation and may impair renal function, affecting patient outcome. EA-230 exerted immunomodulatory and renoprotective effects in preclinical models and was safe and showed efficacy in phase I and II human studies.