Open AccessAlmitrine Infusion in Severe Acute Respiratory Syndrome Coronavirus 2-Induced Acute Respiratory Distress Syndrome: A Single-Center Observational Study*
Author(s) -
Morgan Caplan,
Julien Goutay,
Anne Big,
Emmanuelle Jaillette,
Raphaël Favory,
Daniel Mathieu,
Erika Parmentier-Decrucq,
Julien Poissy,
Thibault Duburcq
Publication year - 2020
Publication title -
critical care medicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000004711
Subject(s) - medicine , hypoxemia , anesthesia , hypoxic pulmonary vasoconstriction , pneumonia , respiratory distress , respiratory disease , lung , vasoconstriction
Treating acute respiratory failure in patients with coronavirus disease 2019 is challenging due to the lack of knowledge of the underlying pathophysiology. Hypoxemia may be explained in part by the loss of hypoxic pulmonary vasoconstriction. The present study assessed the effect of almitrine, a selective pulmonary vasoconstrictor, on arterial oxygenation in severe acute respiratory syndrome coronavirus 2-induced acute respiratory distress syndrome.