Open AccessCircadian Gene Expression Rhythms During Critical Illness
Author(s) -
Matthew B. Maas,
Marta Iwanaszko,
Bryan Lizza,
Kathryn J. Reid,
Rosemary Braun,
Phyllis C. Zee
Publication year - 2020
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000004697
Subject(s) - circadian rhythm , medicine , clock , transcriptome , rhythm , critical illness , actigraphy , circadian clock , bioinformatics , critically ill , gene expression , gene , biology , genetics
Core clock genes regulate tissue-specific transcriptome oscillations that synchronize physiologic processes throughout the body, held in phase by the central circadian rhythm. The central circadian rhythm rapidly dampens with onset of critical illness, but the effect of critical illness on gene expression oscillations is unknown. The objective of this study was to characterize the rhythmicity and phase coherence of core clock genes and the broader transcriptome after onset of critical illness.