Open AccessConsumptive Coagulopathy Involving Amniotic Fluid Embolism: The Importance of Earlier Assessments for Interventions in Critical Care
Author(s) -
Tomoaki Oda,
Naoaki Tamura,
Rui Ide,
Takeshi Itoh,
Yoshimasa Horikoshi,
Masako Matsumoto,
Megumi Narumi,
Yukiko Kohmura-Kobayashi,
Naomi Furuta-Isomura,
Chizuko Yaguchi,
Toshiyuki Uchida,
Kazunao Suzuki,
Hiroaki Itoh,
Naohiro Kanayama
Publication year - 2020
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000004665
Subject(s) - amniotic fluid embolism , medicine , coagulopathy , amniotic fluid , fibrinogen , consumptive coagulopathy , disseminated intravascular coagulation , thromboelastography , partial thromboplastin time , embolism , surgery , obstetrics , anesthesia , coagulation , pregnancy , fetus , genetics , biology
Amniotic fluid embolism is a rare disease that induces fatal coagulopathy; however, due to its rarity, it has not yet been examined in detail. The strict diagnostic criteria by Clark for amniotic fluid embolism include severe coagulopathy complicated by cardiopulmonary insufficiency, whereas the Japanese criteria also include postpartum hemorrhage or Disseminated Intravascular Coagulation in clinical practice. Amniotic fluid embolism cases with preceding consumptive coagulopathy may exist and are potential clinical targets for earlier assessments and interventions among amniotic fluid embolism cases fulfilling the Japanese, but not Clark criteria. The present study was performed to compare coagulopathy in the earlier stage between the amniotic fluid embolism patients diagnosed by Clark criteria (Clark group, n = 6), those by the Japanese criteria (Non-Clark group, n = 10), and peripartum controls and identify optimal clinical markers for earlier assessments of amniotic fluid embolism-related consumptive coagulopathy.