Open AccessFactors Disrupting Melatonin Secretion Rhythms During Critical Illness
Author(s) -
Matthew B. Maas,
Bryan Lizza,
Sabra M. Abbott,
Eric M. Liotta,
Maged Gendy,
John Eed,
Andrew M. Naidech,
Kathryn J. Reid,
Phyllis C. Zee
Publication year - 2020
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000004333
Subject(s) - medicine , circadian rhythm , melatonin , sepsis , zeitgeber , encephalopathy , glasgow coma scale , intensive care medicine , anesthesia , physiology , circadian clock
The circadian system modulates many important physiologic processes, synchronizing tissue-specific functions throughout the body. We sought to characterize acute alterations of circadian rhythms in critically ill patients and to evaluate associations between brain dysfunction, systemic multiple organ dysfunction, environmental stimuli that entrain the circadian rhythm (zeitgebers), rest-activity rhythms, and the central circadian rhythm-controlled melatonin secretion profile.