Open AccessFlow-Controlled Ventilation Attenuates Lung Injury in a Porcine Model of Acute Respiratory Distress Syndrome: A Preclinical Randomized Controlled Study
Author(s) -
Johannes Schmidt,
Christin Wenzel,
Sashko Spassov,
Silke Borgmann,
Ziwei Lin,
Jakob Wollborn,
Jonas Weber,
Jörg Haberstroh,
Stephan Meckel,
Sebastian Eiden,
Steffen Wirth,
Stefan Schumann
Publication year - 2020
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000004209
Subject(s) - medicine , ventilation (architecture) , tidal volume , mechanical ventilation , anesthesia , lung , positive end expiratory pressure , oxygenation , respiratory distress , respiratory system , mechanical engineering , engineering
Lung-protective ventilation for acute respiratory distress syndrome aims for providing sufficient oxygenation and carbon dioxide clearance, while limiting the harmful effects of mechanical ventilation. "Flow-controlled ventilation", providing a constant expiratory flow, has been suggested as a new lung-protective ventilation strategy. The aim of this study was to test whether flow-controlled ventilation attenuates lung injury in an animal model of acute respiratory distress syndrome.