Open AccessBiomarkers of Delirium Duration and Delirium Severity in the ICU*
Author(s) -
Babar Khan,
Anthony J. Perkins,
Nagendra Prasad,
Anantha Shekhar,
Noll L. Campbell,
Sujuan Gao,
Sophia Wang,
Sikandar Khan,
Edward R. Marcantonio,
Homer L. Twigg,
Malaz Boustani
Publication year - 2020
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000004139
Subject(s) - delirium , medicine , quartile , glasgow coma scale , coma (optics) , c reactive protein , risk factor , anesthesia , intensive care medicine , inflammation , confidence interval , physics , optics
Both delirium duration and delirium severity are associated with adverse patient outcomes. Serum biomarkers associated with delirium duration and delirium severity in ICU patients have not been reliably identified. We conducted our study to identify peripheral biomarkers representing systemic inflammation, impaired neuroprotection, and astrocyte activation associated with delirium duration, delirium severity, and in-hospital mortality.