Open AccessSuppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes
Author(s) -
Lin Piao,
YongHu Fang,
Robert B. Hamanaka,
Gökhan M. Mutlu,
Cameron Dezfulian,
Stephen L. Archer,
Willard W. Sharp
Publication year - 2020
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000004095
Subject(s) - medicine , resuscitation , cardiopulmonary resuscitation , myocardial stunning , anesthesia , mitochondrial permeability transition pore , cardiogenic shock , superoxide , cardiology , ischemia , myocardial infarction , apoptosis , programmed cell death , chemistry , biochemistry , enzyme
Cardiogenic shock following cardiopulmonary resuscitation for sudden cardiac arrest is common, occurring even in the absence of acute coronary artery occlusion, and contributes to high rates of postcardiopulmonary resuscitation mortality. The pathophysiology of this shock is unclear, and effective therapies for improving clinical outcomes are lacking.