Open AccessSystemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis*
Author(s) -
Jane Whitney,
Binqing Zhang,
Natalka Koterba,
FaMing Chen,
Jenny Bush,
Kathryn Graham,
Simon F. Lacey,
J. Joseph Melenhorst,
David T. Teachey,
Janell L. Mensinger,
Nadir Yehya,
Scott L. Weiss
Publication year - 2020
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000004091
Subject(s) - medicine , sepsis , vascular endothelial growth factor , angiopoietin , von willebrand factor , endothelial activation , thrombomodulin , respiratory distress , immunology , angiopoietin receptor , endothelium , angiogenesis , surgery , platelet , thrombin , vegf receptors
Systemic endothelial activation may contribute to sepsis-associated organ injury, including acute respiratory distress syndrome. We hypothesized that children with extrapulmonary sepsis with versus without acute respiratory distress syndrome would have plasma biomarkers indicative of increased endothelial activation and that persistent biomarker changes would be associated with poor outcome.