Open AccessAllergic Immune Diseases and the Risk of Mortality Among Patients Hospitalized for Acute Infection*
Author(s) -
Philip A. Verhoef,
Sivasubramanium V. Bhavani,
Kyle Carey,
Matthew M. Churpek
Publication year - 2019
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000004020
Subject(s) - medicine , asthma , sepsis , disease , odds ratio , population , immune system , immunology , allergy , retrospective cohort study , immune dysregulation , atopic dermatitis , cohort , environmental health
The immune response during sepsis remains poorly understood and is likely influenced by the host's preexisting immunologic comorbidities. Although more than 20% of the U.S. population has an allergic-atopic disease, the type 2 immune response that is overactive in these diseases can also mediate beneficial pro-resolving, tissue-repair functions. Thus, the presence of allergic immunologic comorbidities may be advantageous for patients suffering from sepsis. The objective of this study was to test the hypothesis that comorbid type 2 immune diseases confer protection against morbidity and mortality due to acute infection.