Open AccessHost-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress Syndrome*
Author(s) -
Georgios D. Kitsios,
Liheng Yang,
Dimitris V. Manatakis,
Mehdi Nouraie,
John Evankovich,
William Bain,
D.G. Dunlap,
Faraaz Shah,
Ian J. Barbash,
Sarah F. Rapport,
Yingze Zhang,
Rebecca DeSensi,
Nathaniel M. Weathington,
Bill B. Chen,
Prabir Ray,
Rama K. Mallampalli,
Panayiotis V. Benos,
Janet Lee,
Alison Morris,
Bryan J. McVerry
Publication year - 2019
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000004018
Subject(s) - medicine , biomarker , ards , prospective cohort study , intensive care medicine , lung , biochemistry , chemistry
Classification of patients with acute respiratory distress syndrome into hyper- and hypoinflammatory subphenotypes using plasma biomarkers may facilitate more effective targeted therapy. We examined whether established subphenotypes are present not only in patients with acute respiratory distress syndrome but also in patients at risk for acute respiratory distress syndrome (ARFA) and then assessed the prognostic information of baseline subphenotyping on the evolution of host-response biomarkers and clinical outcomes.