Open AccessUse of Cell Cycle Arrest Biomarkers in Conjunction With Classical Markers of Acute Kidney Injury
Author(s) -
Michael Joannidis,
Lui G. Forni,
Michael Haase,
Jay L. Koyner,
Jing Shi,
Kianoush Kashani,
Lakhmir S. Chawla,
John A. Kellum
Publication year - 2019
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000003907
Subject(s) - medicine , acute kidney injury , oliguria , kidney disease , creatinine , dialysis , azotemia , renal replacement therapy , clinical endpoint , hazard ratio , hemodialysis , intensive care medicine , urology , renal function , randomized controlled trial , confidence interval
Decreased urine output and/or increased serum creatinine may herald the development of acute kidney injury or reflect normal physiology. In this secondary analysis of the Sapphire study, we examined biomarkers of cell cycle arrest in the settings of oliguria and/or azotemia to improve risk assessment when used with conventional indices in predicting severe acute kidney injury (Kidney Disease: Improving Global Outcomes 3 defined by the need for renal replacement therapy or changes in urine output, serum creatinine or both) or death.