Open AccessMitochondrial DNA Haplogroups and Delirium During Sepsis
Author(s) -
David C. Samuels,
Todd Hulgan,
Joshua P. Fessel,
Frederic T. Billings,
Jennifer L. Thompson,
Rameela Chandrasekhar,
Timothy D. Girard
Publication year - 2019
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000003810
Subject(s) - haplogroup , medicine , delirium , sepsis , mitochondrial dna , genetics , haplotype , intensive care medicine , genotype , biology , gene
Studies suggest that mitochondrial dysfunction underlies some forms of sepsis-induced organ failure. We sought to test the hypothesis that variations in mitochondrial DNA haplogroup affect susceptibility to sepsis-associated delirium, a common manifestation of acute brain dysfunction during sepsis.