Open AccessA Pilot Study Identifying Brain-Targeting Adaptive Immunity in Pediatric Extracorporeal Membrane Oxygenation Patients With Acquired Brain Injury
Author(s) -
Sterling B. Ortega,
Poornima Pandiyan,
Jana Windsor,
Vanessa Torres,
Uma Maheswari Selvaraj,
Amy Lee,
Michael C. Morriss,
Fenghua Tian,
Lakshmi Raman,
Ann M. Stowe
Publication year - 2019
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000003621
Subject(s) - extracorporeal membrane oxygenation , medicine , oxygenation , immune system , anesthesia , immunology
Extracorporeal membrane oxygenation provides short-term cardiopulmonary life support, but is associated with peripheral innate inflammation, disruptions in cerebral autoregulation, and acquired brain injury. We tested the hypothesis that extracorporeal membrane oxygenation also induces CNS-directed adaptive immune responses which may exacerbate extracorporeal membrane oxygenation-associated brain injury.