Open AccessManagement of the Critically Ill Adult Chimeric Antigen Receptor-T Cell Therapy Patient: A Critical Care Perspective
Author(s) -
Cristina Gutiérrez,
Colleen McEvoy,
Elena Mead,
Robert S. Stephens,
Laveena Munshi,
Michael E. Detsky,
Stephen M. Pastores,
Joseph L. Nates
Publication year - 2018
Publication title -
critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.002
H-Index - 271
eISSN - 1530-0293
pISSN - 0090-3493
DOI - 10.1097/ccm.0000000000003258
Subject(s) - medicine , critically ill , perspective (graphical) , chimeric antigen receptor , intensive care medicine , critical illness , cell therapy , immunology , immunotherapy , immune system , cell , genetics , artificial intelligence , biology , computer science
Chimeric antigen receptor T-cell therapy, a type of immune effector therapy for cancer, has demonstrated encouraging results in clinical trials for the treatment of patients with refractory hematologic malignancies. Nevertheless, there are toxicities specific to these treatments that, if not recognized and treated appropriately, can lead to multiple organ failure and death. This article is a comprehensive review of the available literature and provides, from a critical care perspective, recommendations by experienced intensivists in the care of critically ill adult chimeric antigen receptor T-cell patients.