Open AccessAmelanotic metastatic gastric malignant melanoma: a case report
Author(s) -
Min Zhu,
Daya Zhang,
Guanjun Zhang,
Zhanbo Wang,
Ming-Yang Lid
Publication year - 2021
Publication title -
anti-cancer drugs
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 93
eISSN - 1473-5741
pISSN - 0959-4973
DOI - 10.1097/cad.0000000000001227
Subject(s) - amelanotic melanoma , medicine , melanoma , pathological , metastasis , incidence (geometry) , cancer , dermatology , neoplasm , oncology , pathology , cancer research , physics , optics
Melanoma is a malignant form of cutaneous cancer with an increasing incidence since 1970s, accounting for nearly 75% of the death related to skin cancer especially in western countries. Highest recurrence and mortality were observed for the subtype with distal metastasis, demonstrating poor outcomes. However, high incidence of gastrointestinal metastasis of malignant melanoma is frequently misdiagnosed due to lack of specific clinical manifestations, especially for the rare observed cases presented amelanotic appearance, accounting for about 2% of all metastatic cases. In the present study, we reported a 36-year-old male patient, who was firstly diagnosed as gastric cancer, and then was confirmed as amelanotic melanoma metastasis by pathological examination, demonstrating positive for melanoma markers including Melan A, S-100, Hmb45 and CD79a. In conclusion, for the amelanotic neoplasm observed during gastroscopy in patients with melanoma history, pathological examination should be carried out to confirm the possibility of melanoma metastasis, providing evidences for the following treatment.