Open AccessAbnormal bone marrow microenvironment: the “harbor” of acute lymphoblastic leukemia cells
Author(s) -
Zehui Chen,
Yuyan Zheng,
YaLing Yang,
Junnan Kang,
M. James You,
Chen Tian
Publication year - 2021
Publication title -
blood science
Language(s) - English
Resource type - Journals
ISSN - 2543-6368
DOI - 10.1097/bs9.0000000000000071
Subject(s) - bone marrow , haematopoiesis , leukemia , stem cell , immunology , biology , cancer research , lymphoblastic leukemia , acute leukemia , niche , medicine , microbiology and biotechnology , ecology
Bone marrow (BM) microenvironment regulates and supports the production of blood cells which are necessary to maintain homeostasis. In analogy to normal hematopoiesis, leukemogenesis is originated from leukemic stem cells (LSCs) which gives rise to more differentiated malignant cells. Leukemia cells occupy BM niches and reconstruct them to support leukemogenesis. The abnormal BM niches are the main sanctuary of LSCs where they can evade chemotherapy-induced death and acquire drug resistance. In this review, we focus on the protective effects of BM niche cells on acute lymphoblastic leukemia cells.