Open AccessThe role of cholesterol metabolism in leukemia
Author(s) -
Liang Zhao,
Huien Zhan,
Xinya Jiang,
Yangqiu Li,
Hui Zeng
Publication year - 2019
Publication title -
blood science
Language(s) - English
Resource type - Journals
ISSN - 2543-6368
DOI - 10.1097/bs9.0000000000000016
Subject(s) - leukemia , malignancy , cholesterol , cancer research , biology , bioinformatics , medicine , immunology
Leukemia is a common hematological malignancy with overall poor prognosis. Novel therapies are needed to improve the outcome of leukemia patients. Cholesterol metabolism reprogramming is a featured alteration in leukemia. Many metabolic-related genes and metabolites are essential to the progress and drug resistance of leukemia. Exploring potential therapeutical targets related to cholesterol homeostasis is a promising area. This review summarized the functions of cholesterol and its derived intermediate metabolites, and also discussed potential agents targeting this metabolic vulnerability in leukemia.