Open AccessMacrophages in leukemia microenvironment
Author(s) -
Lina Wang,
Zheng Ge
Publication year - 2019
Publication title -
blood science
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2543-6368
DOI - 10.1097/bs9.0000000000000014
Subject(s) - leukemia , tumor microenvironment , cancer research , metastasis , angiogenesis , macrophage , immunology , biology , medicine , cancer , tumor cells , in vitro , biochemistry
Macrophages, the important component of tissue microenvironment, play important roles in both physiological and pathological processes, including tumor and leukemia. Tumor-associated macrophages are involved in tumor proliferation, angiogenesis, invasion, metastasis, and chemotherapy resistance. In leukemia, macrophages are educated by leukemia microenvironment to obtain specific activated phenotype and participate in leukemia progression. Recent studies have shown that accumulation of macrophages in leukemia patients or mouse model is correlated with poor prognosis. Hence, increasing attentions have been paid to study the characteristics of them and to develop novel therapeutic strategies targeting macrophages against leukemia. In this article, we summarize recent development of macrophages in leukemia microenvironment.