Open AccessLegg-Calve-Perthes Disease
Author(s) -
Harry K.W. Kim
Publication year - 2011
Publication title -
journal of pediatric orthopaedics/journal of pediatric orthopedics
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.318
H-Index - 96
eISSN - 1539-2570
pISSN - 0271-6798
DOI - 10.1097/bpo.0b013e318223b4bd
Subject(s) - legg calve perthes disease , medicine , femoral head , etiology , disease , deformity , pathogenesis , bioinformatics , surgery , pathology , biology
Legg-Calve-Perthes disease is a complex pediatric hip disorder with many uncertainties. Various theories on its etiology have been proposed but none have been validated conclusively. Through experimental studies, however, some insight into the pathogenesis of a femoral head deformity after ischemic necrosis has been gained. These studies reveal that mechanical and biological factors contribute to the development of the femoral head deformity. Better understanding of the pathobiology of Legg-Calve-Perthes disease will lead to the development of more effective treatments, which are able to specifically target the pathogenic processes.