Open AccessDemineralized Bone Matrix for Fracture Healing: Fact or Fiction?
Author(s) -
Ramsey C. Kinney,
Bruce H. Ziran,
Kurt Hirshorn,
Daniel Schlatterer,
Timothy Ganey
Publication year - 2010
Publication title -
journal of orthopaedic trauma
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.221
H-Index - 121
eISSN - 1531-2291
pISSN - 0890-5339
DOI - 10.1097/bot.0b013e3181d07ffa
Subject(s) - dbm , demineralized bone matrix , medicine , bone healing , surgery , dentistry , amplifier , cmos , electronic engineering , engineering
Demineralized bone matrix (DBM) has been touted as an excellent grafting material; however, there are no Level I studies that use DBM alone in humans to back up this claim. DBM functions best in a healthy tissue bed but should be expected to have little impact in an anoxic or avascular tissue bed, a situation often encountered in traumatic orthopaedic pathologies. Moreover, there is some evidence of differential potencies of DBM preparations based on donor variability and the manufacturing process. DBM efficacy may also be related to its formulation and the various carriers used. The fact that DBM is an allogeneic material opens up the potential for disease transmission. In addition, DBM activity may be altered by the hormonal status or nicotine use of a patient. In summary, although DBM has proven effective for bone induction in lower form animals, the translation to human clinical use for fracture healing, and the burden of proof, remains.