Open AccessPrecision Medicine Applications to Manage Multiply Injured Patients With Orthopaedic Trauma
Author(s) -
Todd O. McKinley,
Felipe A. Lisboa,
Annamarie D. Horan,
Greg E. Gaski,
Samir Mehta
Publication year - 2019
Publication title -
journal of orthopaedic trauma
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.221
H-Index - 121
eISSN - 1531-2291
pISSN - 0890-5339
DOI - 10.1097/bot.0000000000001468
Subject(s) - medicine , polytrauma , nonunion , precision medicine , demographics , psychological intervention , trauma center , intensive care medicine , surgery , physical therapy , retrospective cohort study , pathology , psychiatry , sociology , demography
Precision medicine offers potential for improved outcomes by tailoring interventions based on patient-specific demographics and disease-specific data. Precision methods are relatively unexplored in trauma patients. New research is being looked at for precision methods to treat patients with large extremity wounds, nonunions, and fractures associated with polytrauma. Precision-based clinical decision tools are being validated to optimize timing for open wound definitive closure. Early patient-specific biomarkers to stratify nonunion risk within 1 week of fracture are being explored. Patient-specific data to stage timing of major fracture interventions in multiply injured patients are being interrogated.