Open AccessThe latest in systemic lupus erythematosus-accelerated atherosclerosis: related mechanisms inform assessment and therapy
Author(s) -
Brenna D Appleton,
Amy S. Major
Publication year - 2020
Publication title -
current opinion in rheumatology/current opinion in rheumatology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.452
H-Index - 112
eISSN - 1080-8175
pISSN - 1040-8711
DOI - 10.1097/bor.0000000000000773
Subject(s) - medicine , disease , inflammation , mechanism (biology) , immune system , systemic inflammation , immunology , atherosclerotic cardiovascular disease , comorbidity , systemic lupus erythematosus , autoimmune disease , intensive care medicine , bioinformatics , philosophy , epistemology , biology
Accelerated atherosclerosis is a significant comorbidity and the leading cause of death for patients with systemic lupus erythematosus (SLE). It is now apparent that SLE-accelerated atherosclerosis is not driven solely by traditional cardiovascular risk factors, adding complexity to disease characterization and mechanistic understanding. In this review, we will summarize new insights into SLE-accelerated atherosclerosis evaluation, treatment, and mechanism.