Open AccessThe Role of Mitochondrial Stress in Muscle Wasting Following Severe Burn Trauma
Author(s) -
John O. Ogunbileje,
David N. Herndon,
Andrew J. Murton,
Craig Porter
Publication year - 2017
Publication title -
journal of burn care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.679
H-Index - 78
eISSN - 1559-0488
pISSN - 1559-047X
DOI - 10.1097/bcr.0000000000000553
Subject(s) - hypermetabolism , wasting , medicine , skeletal muscle , oxidative stress , mitochondrion , burn injury , catabolism , pathophysiology , endocrinology , microbiology and biotechnology , surgery , biology , metabolism
Increased resting metabolic rate and skeletal muscle wasting are hallmarks of the pathophysiological stress response to severe burn trauma. However, whether these two responses occur independently in burn patients or are in fact related remains unclear. In light of recent evidence demonstrating that increased proteolysis in skeletal muscle of burned patients is accompanied by mitochondrial hypermetabolism, oxidative stress, and protein damage; in this article, we discuss the evidence for a role for the mitochondrion in skeletal muscle wasting following severe burn trauma. In particular, we focus on the role of mitochondrial superoxide production in oxidative stress and subsequent proteolysis, and discuss the role of the mitochondrion as a signaling organelle resulting in protein catabolism in other cellular compartments following severe burn trauma.